Original Everlong Tablets in Karachi – Everlong Tablets in Lahore – Everlong Tablets in Multan

Original Everlong Tablets in Karachi – Everlong Tablets in Lahore – Everlong Tablets in Multan

Dapoxetine, marketed as EverlongTablets in Karachi among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. Everlong Tablets in Karachi works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of the selective serotonin reuptake inhibitor (SSRI) family, EverlongTablets in Karachi was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

Originally created by MAARK pharmaceutical company, Everlong Tablets in Karachi was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Everlong Tablets in Karachi is sold in several European and Asian countries, and in Mexico. In the US, Everlong Tablets in Karachi has been in phase III development since 2003. However, it is expected to be marketed soon. In 2012, Menarini acquired the rights to commercialise Everlong Tablets in Karachi in Europe, most of Asia, Africa, Latin America and the Middle East.

Premature ejaculation with Everlong Tablets in Karachi

Randomized, double blind, placebo-controlled trials have confirmed the efficacy of EverlongTablets in Karachi for the treatment of PE. Different dosage has different impacts on different types of PE. EverlongTablets in Karachi 60 mg significantly improves the mean intravaginal ejaculation latency time (IELT) compared to that of dapoxetine 30 mg in men with lifelong PE, but there is no difference in men with acquired PE.

Everlong Tablets inKarachi Dapoxetine, given 1–3 hours before sexual episode, prolongs IELT and increases the sense of control and sexual satisfaction in men of 18 to 64 years of age with PE. Since PE is associated with personal distress and interrelationship difficulty, EverlongTablets in Karachi provides help for men with PE to overcome this condition. With no drug approved specifically for treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used off-label to treat PE. Waldinger's meta-analysis shows that the use of these conventional antidepressants increases IELT two- to nine-fold above baseline, compared to three- to eight-fold when

The Best for Men Erection and Everlong Tablets in Pakistan Buy Online

Everlong Tablets inKarachi is used. However, these SSRIs may need to be taken daily in order to achieve meaningful efficacy, and their comparatively longer half-lives increase the risk of drug accumulation and a corresponding increase of adverse effects such as reduced libido. EverlongTablets in Karachi, on the other hand, is generally categorized as a fast-acting SSRI. Everlong Tablets inKarachi is more rapidly absorbed and mostly eliminated from the body within a few hours. This pharmacokinetics is more favorable in that they might minimize drug accumulation in the body, habituation, and side effects.

Contraindications about Everlong Tablets in Pakistan

A contraindication is a situation in which a drug should not be used, because it may be harmful to the patient. Everlong Tablets in Pakistan should not be used in men with moderate to severe hepatic impairment and in those receiving CYP3A4 inhibitors such as ketoconazole, ritonavir, and telithromycin. Everlong Tablets in Pakistan can also not be used in patients with heart failure, permanent pacemaker, or other significant ischemic heart disease. Caution is advised in men receiving thioridazine, monoamine oxidase inhibitors, SSRIs, serotonin-norepinephrine reuptake inhibitors, or tricyclic antidepressant. If a patient stops taking one of these drugs, he should wait for 14 days before taking EverlongTablets in Pakistan.

Adverse effects of Everlong Tablets in Pakistan

The most common effects when taking dapoxetine are nausea, dizziness, dry mouth, headache, diarrhea, and insomnia. Discontinuation due to adverse effects is dose related. According to McMahon in recent study in Asia, the rate of discontinuation is 0.3%, 1.7%, and 5.3% of 1067 studied subjects with placebo, dapoxetine 30 mg, and dapoxetine 60 mg respectively. Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, Everlong Tabletsin Pakistan is associated with low rates of sexual dysfunction. Taken as needed, Everlong Tablets in Pakistan has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%).

Overdose of Everlong Tablets in Pakistan

No case of drug overdose has been reported during clinical trials of Everlong Tablets in Karachi.

Mechanism of actions of Everlong Tablets in Pakistan

The mechanism through which Everlong Tablets in Pakistan affects premature ejaculation is clear. However, it is presumed that EverlongTablets in Karachi works by inhibiting serotonin transporter and subsequently increasing serotonin's action at pre and postsynaptic receptors Human ejaculation is regulated by various areas in the central nervous system (CNS).

 The ejaculatory pathway originates from spinal reflex at the thoracolumbar and lumbosacral level of spinal cord activated by stimuli from male genital. These signals are relayed to the brain stem, which then is influenced by a number of nuclei in the brain such as medial preoptic and paraventricular nulcei. Clement's study performed on anaesthetized male rats showed that acute administration of Everlong Tablets in Karachi inhibits ejaculatory expulsion reflex at supraspinal level by modulating activity of lateral paragigantocellular nucleus (LPGi) neurons. These effects cause an increase in pudendal motoneuron reflex discharge (PMRD) latency. However, it is unclear whether Everlong Tablets inKarachi acts directly on LPGi or on the descending pathway in which LPGi located.

Safety and tolerability of Everlong Tablets in Pakistan

Cardiovascular safety of Everlong Tablets in Karachi

The cardiovascular safety profile of Everlong Tablets in Karachi has been studied extensively during the drug development. Phase I trials showed that Everlong Tablets in Karachi had neither clinical significant electrocardiographic effects nor delayed repolarization effects, with dosing up to four-fold greater than the maximum recommended dosage which is 60 mg. Phase III studies in men with PE showed a safety and well tolerate profile of Everlong Tablets in Karachi with dosing of 30 and 60 mg. There is no cardiovascular adverse had been found.

Neurocognitive safety of Everlong Tablets in Pakistan

Studies of SSRIs in patients with major psychiatric disorders prove that SSRIs are potentially associated with certain Neurocognitive adverse effects such as anxiety, akathisia, hypomania, changes in mood, or suicidal thought. However, there is no study on the effects of SSRIs in men with PE. McMahon’s study in 2012 showed that Everlong Tablets in Karachi has no effect on mood and is not associated with anxiety or sociality.

Withdrawal syndrome of Everlong Tablets in Pakistan

The incidence of antidepressant discontinuation syndrome symptoms in men using Everlong Tabletsin Karachi to treat premature ejaculation has been described by reviewers as low or no different from the incidence of such symptoms in men withdrawn from placebo treatment. The lack of chronic serotonergic stimulation with on-demand dapoxetine minimizes the potentiation action of serotonin at synaptic cleft, thus decreasing the risk of DESS.

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